Biomarkers of ageing One of the more obvious uses of ProQuant™ is to look for biomarkers of disease.  We used ProQuant™ to investigate potential biomarkers of ageing, using serum samples from subjects of different ages.  Across the 300 proteins measured none were...

Delving into proteoforms with higher throughput ProQuant™ was used to study apolipoprotein E (apoE), a polymorphic protein with key roles in longevity and Alzheimer’s disease.  Our experiments testing different samples from in vitro and in vivo experiments identified...

Where is my protein labelled? There are many applications for which labelling of proteins is commonly used, for example tracking of the protein of interest within a complex biological system, and even in vivo.  However, the specific residues labelled and the extent of...

What is the pattern of glycation seen in diabetes and how does it correlate with a spot glucose measure? Glycated haemoglobin (HbA1c) is used clinically as a biomarker for elevated blood glucose, because the rate of formation of glycated haemoglobin is proportional to...